Henry Cuellar completed the Stand With Crypto Questionnaire and indicated strong support for developing a clear, predictable federal regulatory framework for digital assets. He advocates for legislation that defines digital assets as securities or commodities, provides clear pathways for businesses, and protects the right to self-custody, while also supporting an end to de-banking practices for lawful crypto users. Cuellar has co-sponsored and voted for various bills, including the FIT21 Act, reflecting these positions.